Net4CGD new scientific article to be published in Journal of Allergy and Clinical Immunology - 2016
Net4CGD scientists in Frankfurt, Paris and London report that hyperinflammation in CGD leads to impairment of hematopoietic stem cell functions in the prestigious Journal of Allergy and Clinical Immunology. Persistent chronic inflammation in CGD is associated with hematopoietic proliferative stress leading to a decrease in the functional activity of hematopoietic stem cells. Proactive treatment of CGD patients with anti-inflammatory drugs might therefore reduce chronic sterile inflammation in CGD and in addition could have an impact on the quantity and quality of hematopoietic stem cells available for autologous gene therapy.
The article will be published in 2016.