A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells

Müller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M.  Nucleic Acids Res. 2015 Feb 18;43(3):1577-92. doi: 10.1093/nar/gkv019. Epub 2015 Jan 20.

PubMed Access

Gene Therapy for X-Linked Chronic Granulomatous Disease (Net4CGD)

Net4CGD Project summary published in Human Gene Therapy Clinical Development, June 2015;26(2):88-90. doi: 10.1089/humc.2015.2526.

Open Access

Generation of X-CGD cells for vector evaluation from healthy donor CD34+ HSCs by shRNA-mediated knock down of gp91phox

Brendel Cl, Kaufmann KB, Krattenmacher A, Pahujani S, Grez M.
Molecular Therapy - Methods & Clinical Development. 2014; 1:14037. doi:10.1038/mtm.2014.37.

PubMed Access

Gene therapy on the move

Kaufmann KB, Büning H, Galy A, Schambach A, Grez M.
EMBO Mol Med. 2013 Nov;5(11):1642-61. doi: 10.1002/emmm.201202287. Epub 2013 Sep 17.

PubMed Access